Anisomeles indica (L.) Kuntze
Traditional Knowledge
Useful plant parts :
Aerial part, leaf and medicated oil
Uses in traditional medicine :
- Infusion of aerial parts are taken for intestinal and stomach complications
- One tea spoon of leaf juice is taken for cough and cold
- Leaf juice is given for children in colic dyspepsia and for fever due to teething
- Oil is used in uterine affections
- Used to treat rheumatism and kidney stones
Scientific Research
Chemical constituents:
Diterpene: ovatodiolide from leaves; benzenoids, phenyl propanoids, flavonoids: pedalitin and scutellarein derivatives, ovatodiolide derivative from whole plant
Bioactivity :
Water extracts of leaves and stem from pre-flowering plants: analgaesic, antihyperalgesic, antihistamine, membrane stabilizing, COX inhibitor and free radical scavenger; ovatodiolide, pedalitin and phenyl propanoid: anti-HIV activity, antiplatelet aggregation, effective for improving renal cell carcinoma therapy, anti-inflammatory, anticancer
Clinical:
References : Alam, M. S. et al., (2000), HIV-inhibitory diterpenoid from Anisomeles indica, Fitoterapia, 71(5), 574-576. Anjaneyulu, A. S. R. et al., (1977), Novel hydroxy lignans from the heartwood of Gmelina arborea, Tetrahedron, 33(1), 133-143. Chen, Y. L. et al., (2008), Bioactive Cembrane Diterpenoids of Anisomeles indica, Journal of Natural Products, 71(7), 1207-1212. Ho, J. Y. et al., (2013), Ovatodiolide Targets β-Catenin Signaling in Suppressing Tumorigenesis and Overcoming Drug Resistance in Renal Cell Carcinoma, Evid Based Complement Alternat Med. Hsieh, S. C. et al., (2008), Inhibition of pro-inflammatory mediators and tumor cell proliferation by Anisomeles indica extracts, Journal of Ethnopharmacology, 118, 65-70. Rao, Y. K. et al., (2009), The constituents of Anisomeles indica and their anti-inflammatory activities, Journal of Ethnopharmacology, 121, 292-296. Rao, Y. K. et al., (2013), Ovatodiolide inhibits the maturation of allergen-induced bone marrow-derived dendritic cells and induction of Th2 cell differentiation, Int Immunopharmacol.
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