Croton tiglium L.
Traditional Knowledge
Useful plant parts :
Root and seed
Uses in traditional medicine :
- Very low doses of dried seeds with boiled milk acts as a very strong drastic purgative
- Roots ground with Aristolochia indica (Sapsanda) roots are applied on poisonous snake bites
- Seeds are poisonous and used to treat rheumatism, glandular swellings, chronic bronchitis, pulmonary affections, dropsy, intestinal obstructions, fever, constipation and ascites
Scientific Research
Chemical constituents:
Isoguanosine from plant; phorbol diesters from seeds
Bioactivity :
Seeds: biochemical tool for standard tumor promoting agent in carcinogenesis experiments; methanol extract of seeds: inhibitor of HIV-1 induced cytopathic effect
Clinical:
Caution : Ingestion as few as four seeds have proven to be fatal
References : El-Mekkawy, S. et al., (2000), Anti-HIV-1 phorbol esters from the seeds of Croton tiglium, Phytochemistry, 53, 457-464. Kim, J. H. et al., (1994), Isolation of isoguanosine from Croton tiglium and its antitumor activity, Archives of pharmacal research, 17(2), 115-118. Kinghorn, A. D. and Seo, E. K., (1998), Chromatographic/ chromato- graphic spectroscopic combination methods for the analysis of botanical drugs, Drug Information Journal, 32, 487-495.
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