Datura metel L.
Traditional Knowledge
Useful plant parts :
Leaf, flower, fruit, seed and root
Uses in traditional medicine :
- Root powder is applied on gums for mouth sanitation in elders
- Steamed leaves are applied on painful tumours
- Acts as a narcotic, anodyne, antispasmodic and intoxicant
- Used in rheumatic swellings of joints, lumbago, cataract and other eye diseases, bronchial asthma, rabid dog bites, insanity, hydrophobia, severe colds, tuberculosis, dilation of the eyes and arresting excessive milk secretion
Scientific Research
Chemical constituents:
Tropane alkaloids: atropine, scopolamine from plant; withanolide type steroids: withametelin Q and 12,α-hydroxydaturametelin B, pyrrole derivative and p-hydroxy cinnamic acid amide of tyramine from leaves; complexes of acylated glucose esters from type B glandular trichomes; melatonin and serotonin found in flowers and developing fruits
Bioactivity :
Withametelin Q and 12,α-hydroxydaturametelin: cytotoxic; seed powder: hypoglycaemic; pyrrole derivative: antifungal; leaves: anticholinergic
Clinical:
Caution : Inappropriate consumption of this herb could result in anticholinergic poisoning
References : Bellila, A. et al., (2011), Cytotoxic activity of withanolides isolated from Tunisian Datura metel L., Phytochemistry, 72, 2031-2036. Dabur, R. et al., (2004), A novel antifungal pyrrole derivative from Datura metel leaves, Die Pharmazie – An International Journal of Pharmaceutical Sciences, 59(7), 568-570. Gupta, M. et al., (1992), Withanolides of Datura metel, Phytochemistry, 31(7), 2423-2425. Jakabova, S. et al., (2012), Determination of tropane alkaloids atropine and scopolamine by liquid chromatography-mass spectrometry in plant organs of Datura species, J Chromatogr, 1232, 295-301. King, R. R. and Calhoun, L. A., (1988), 6 2,3-Di-O- and 1,2,3-tri-O- acylated glucose esters from the glandular trichomes of Datura metel, Phytochemistry, 27(12), 3761-3763. Murch, J. S. et al., (2009), Melatonin and serotonin in flowers and fruits of Datura metel L., Journal of Pineal Research, 47(3), 277-283. Murthy, B. K. et al., (2004), Evaluation of hypoglycemic and antihyper- glycemic effects of Datura metel (Linn.) seeds in normal and alloxan- induced diabetic rats, Journal of Ethnopharmacology, 91, 95-98. Phua, D. H. et al., (2008), Two instances of Chinese herbal medicine poisoning in Singapore, Singapore Med J, 49(5), 131-3. Rajesh and Sharma, G. L., (2002), Studies on antimycotic properties of Datur ametel, Journal of Ethnopharmacology, 80(2-3), 193-197. Wannang, N. N. et al., (2009), Evaluation of the analgesic properties of the Datura metel seeds aqueous extract, Journal of Medicinal Plants Research, 3(4), 192-195.
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