Jatropha multifida L.
Traditional Knowledge
Useful plant parts :
Latex, seed and leaf
Uses in traditional medicine :
- Low concentrations of crushed seeds are taken as a purgative and a treatment for vomiting
- Latex of the young shoots are applied on wounds, ulcers and skin infections
- Poultice prepared of ground leaves are applied continuously for a long term for scabies
Scientific Research
Chemical constituents:
Acylphloroglucinols: multifidol and its glucoside, cyclic decapeptide: labaditin from latex; macrocyclic diterpenoid: multifidanol, multifidenol, 15-epi-(4E)-jatrogrossidentadione acetate, lathyrane type diterpene: multifidone, multifolone from stem
Bioactivity :
Crude methanol extract plant: antifungal; hexane, ethyl acetate, chloroform and methanol extracts of root: antibacterial; acylphloroglucinols and labaditin: immunologically active; multifidone: cytotoxic to cancer cells
Clinical:
References : Das, B. et al., (2008), Diterpenoids from Jatropha multifida, Phytochemistry, 69(14), 2639-41. Das, B. et al., (2009), Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida, Bioorg Med Chem Lett, 19(1), 77-9. Das, B. et al., (2009), New macrocyclic diterpenoids from Jatropha multifida, Chem Pharm Bull, 57(3), 318-20. Das, B. et al., (2010), A new macrocyclic diterpenoid from Jatropha multifida, Nat Prod Res, 24(16), 1510-3. Kanth, B. S. et al., (2011), New bioactive macrocyclic diterpenoids from Jatropha multifida, Bioorg Med Chem Lett, 21(22), 6808-10. Kosasi, S. et al., (1989), Multifidol and multifidol glucoside from the latex of Jatropha multifida, Phytochemistry, 28(9), 2439-2441. Hamza, O. J. M. et al., (2006), Antifungal activity of some Tanzanian plants used traditionally for the treatment of fungal infections, Journal of Ethnopharmacology, 108(1), 124-132. Aiyelaagbe, O. O., (2001), Antibacterial activity of Jatropha multifida roots, Fitoterapia, 72(5), 544-546. Kosasi, S. et al., (1989), Labaditin, a novel cyclic decapeptide from the latex of Jatropha multifida L. (Euphorbiaceae): Isolation and sequence determination by means of two-dimensional NMR, FEBS Letters, 256 (1-2), 91-96.
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