Myristica fragrans Houtt.

Myristicaceae

Common Names:
Sadhikka (S)
Sadhikkai (T)
Nutmeg (E)

Traditional Knowledge

Useful plant parts :
Seed

Uses in traditional medicine :

  • A tea spoon of ground seeds in lime juice is given thrice a day after meals for bowel complications

Scientific Research

Chemical constituents:

Tetrahydrofuran lignans: tetrahydrofuroguaiacin B, saucernetindiol, verrucosin, nectandrin A and B, fragransin C, galbacin from dried kernal; macelignans from seed aril; pheylpropene: myristicin from nutmeg essential oil

Bioactivity :

Methanol extracts of aril and seed kernel: antibacterial, antioxidative; macelignans: protect skin keratinocytes from UVB induced damage, antioxidative, immunomodulatory activity; volatile oil of dried seed kernel: anticonvulsant; saucernetindiol, verrucosin, nectandrin B, nectandrin A: AMP- activated protein kinase inhibitor; myristicin: hepatoprotective; n-hexane extract of seeds: memory enhancing, anxiogenic; ethanol extract of fruit: enhance the sexual behavior of male

Clinical:

Herbal shampoo prepared from nutmeg was effective against human head lice

Note :

Aril of the seed is commercially known as mace

References :

Anggakusuma, et al., (2010), Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells, Journal of Dermatological Science, 57, 114–122.

Checker, R. et al., (2008), Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes, International Immunopharmacology, 8, 661–669.

Kwon, H. S. et al., (2008), Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds, Bioorganic & Medicinal Chemistry Letters, 18, 194–198.

Morita, T. et al., (2003), Hepatoprotective Effect of Myristicin from Nutmeg (Myristica fragrans) on Lipopolysaccharide/D-Galactosamine- Induced Liver Injury, Journal of Agriculture and Food Chemistry, 51(6), 1560–1565.

Nguyen, P. H. et al., (2010), AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect, Bioorganic & Medicinal Chemistry Letters, 20, 4128–4131.

Olaleye, M. T. et al., (2006), Antioxidant properties of Myristica fragrans (Houtt) and its effect on selected organs of albino rats, African Journal of Biotechnology, 5(13), 1274-1278.

Parle, M. et al., (2004), Improvement of Mouse Memory by Myristica fragrans Seeds, Journal of Medicinal Food, 7(2), 157-161.

Sonavane, G. S. et al., (2002), Anxiogenic activity of Myristica fragrans seeds, Pharmacology Biochemistry and Behavior, 71(1-2), 239–244.

Sulaiman, S. F. and Leong, O. K., (2012), Antioxidant and anti food-borne bacterial activities of extracts from leaf and different fruit parts of Myristica fragrans Houtt, Food Control, 25, 533-536.

Tajuddin, et al., (2003), Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nut meg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study, BMC Complementary and Alternative Medicine, 3, 6.

Wahab, A. et al., (2009), Anticonvulsant activities of nutmeg oil of Myristica fragrans, Phytother Res, 23(2), 153-8.

Watcharawit, R. and Soonwera, M., (2013), Pediculicidal effect of herbal shampoo against Pediculus humanus capitis in vitro, Trop Biomed, 30(2), 315-24.

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