Plumbago zeylanica L.
Traditional Knowledge
Useful plant parts :
Root
Uses in traditional medicine :
- Dried root infusion in low concentrations is prescribed to improve appetite in elders
- Root powder mixed with neem oil is applied for chronic skin diseases
- Acts as an abortifacient, germicidal and digestive agent
- Used in the treatment of dyspepsia, flatulence, piles, anasarca, diarrhoea, leprosy, influenza and blackwater fever
Scientific Research
Chemical constituents:
Coumarins: seselin and its derivatives, suberosin, xanthyletin, xanthoxyletin and plumbagic acid glucosides, naphthoquinones: plumbagin, chitranone, maritinone, elliptinone and isoshinanolone from roots; guanidine alkaloids: plumbagines A–G, plumbagosides A–D from aerial parts
Bioactivity :
Plumbagin: antimicrobial; antidiabetic, anti-inflammatory, antinociceptive, cytotoxic, anticancer; ethanol extract of whole plant: tumour suppresser; aqueous and alcohol extracts of roots and plumbagin: antioxidative; acetone and ethanol extract of leaves: antifertility activity in females
Clinical:
References : Cong, H. J. et al., (2013), Guanidine alkaloids from Plumbago zeylanica, J Nat Prod, 76(7), 1351-7. De Paiva, S. R. et al., (2003), Antimicrobial Activity in Vitro of Plumbagin Isolated from Plumbago Species, Mem Inst Oswaldo Cruz, 98(7), 959-961. Edwin, S. et al., (2009), Antifertility activity of leaves of Plumbago zeylanica Linn. in female albino rats, Eur J Contracept Reprod Health Care, 14(3), 233-9. Jai, T. et al., (2004), Antioxidant properties of Plumbago zeylanica, an Indian medicinal plant and its active ingredient, plumbagin, Redox Report, 9(4), 219-227. Lin, L. C. et al., (2003), Cytotoxic naphthoquinones and plumbagic acid glucosidesfrom Plumbago zeylanica, Phytochemistry, 62, 619–622. Morais, L. C. S. L. et al., (2004), Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology, Pharmacology, Biochemistry and Behavior, 79, 745–749. Parimala, R. and Sachdanandam, P., (1993), Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma, Molecular and Cellular Biochemistry, 125, 59-63. Sheeja, E. et al., (2010), Bioassay-guided isolation of anti-inflammatory and antinociceptive compound from Plumbago zeylanica leaf, Pharm Biol, 48(4), 381-7. Sunil, C. et al., (2012), Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats, Food Chem Toxicol, 50(12), 4356-63. Xu, T. P. et al., (2013), Plumbagin from Plumbago Zeylanica L. induces apoptosis in human non-small cell lung cancer cell lines through NF- κB inactivation, Asian Pac J Cancer Prev, 14(4), 2325-31.
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