Rauvolfia serpentina (L.) Benth. ex Kurz
Traditional Knowledge
Useful plant parts :
Root
Uses in traditional medicine :
- Decoction of the root increases the uterine contraction in child birth and reduces high blood pressure
- Decoction of the dried root is used as an anthelmintic
- Fresh roots ground with lime is applied as a snake bite remedy
Scientific Research
Chemical constituents:
Indole alkaloids: raumacline and N(b)-methylraumacline, ajmaline, ajmalinine, ajmalicine, serpentine and serpentinine from plant cell cultures and roots
Bioactivity :
Methanolic extract of leaves: antidiarrhoael, sedative; methanolic extract of root: improves glycaemic, antiatherogenic, coronary risk and cardio protective indices in diabetes
Clinical:
Tested to be used in a formulation to treat high blood pressure; Rauwiloid and serpiloid (resepine) derived from plant root used to treat psoriasis
References : Azmi, M. B. et al., (2012), Methanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardio- protective Indices in Alloxan-Induced Diabetic Mice, Adv Pharmacol Sci. Bhatia, B.B., (1942), On the Use of Rauwolfia serpentina in High Blood Pressure, Journal of Indian Medical Association, 11(9), 262. Braaten, D., (1954), Reserpine (Serpasil) and Other Alkaloids of Ruawolfia Serpentina: Chemistry, Pharmacology, and Clinical Applica- tions, Annals of the New York Academy of Sciences, 59, 107–132. Ezeigbo, I. et al., (2012), Antidiarrhoeal activity of leaf methanolic extract of Rauwolfia serpentina, Asian Pac J Trop Biomed, 2(6), 430-2. Neuss, N. et al., (1954), Rauwolfia Serpentina Alkaloids. I. Structure of Reserpine, J. Am. Chem. Soc, 76(9), 2463–2467. Norman, M. et al., (1956), Treatment of psoriasis amd other chronic dermatoses with extracts of Rauwolfia Serpentina, Canadian medical associaton journal, 74, 829-830. Plummer, A. J. et al., (2006), Pharmacology of Rauwolfia Alkaloids, including Reserpine, Chemistry, Pharmacology, and Clinical Applica- tions, 59, 8-21. Polz, L. et al., (1990), Biotransformation of ajmaline in plant cell cultures of Rauwolfia serpentina Benth.: The new indole alkaloids raumacline and N(b)-methylraumacline, Tetrahedron Letters, 31(46), 6693-6696. Vakila, R. J., (2011), Clinical Trial Of Rauwolfia serpentine in Essential Hypertension, British Medical Journal, 11(4), 350-355.
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